Healthy Bison Meatloaf Recipe

If you love the flavor of a hearty meatloaf but want a lighter, nutrient-dense alternative to beef, bison is an excellent choice. Compared to traditional beef, bison is leaner, lower in saturated fat, and packed with high-quality protein, iron, zinc, and vitamin B12. It also contains more omega-3 fatty acids, making it a heart-healthy option that doesn’t sacrifice taste.

Swapping in bison is a simple way to enjoy this comforting meal while supporting your overall health, energy, and wellness.

Nutrient Benefits of Key Ingredients

Every ingredient in this recipe was chosen for both flavor and function:

Bison – A lean red meat rich in protein, iron, zinc, and B vitamins to support energy, muscle repair, and blood health.
Garlic – Contains allicin, a powerful compound with immune-boosting and anti-inflammatory benefits.
Eggs – Supply choline and B vitamins for brain health while helping the meatloaf hold its shape.
Sweet onion – Offers antioxidants and prebiotic fibers that feed a healthy gut.
Parmesan cheese – Enhances flavor with protein and calcium.
Worcestershire sauce & herbs (thyme, oregano, basil, sage, pepper, salt) – Provide antioxidants, digestion support, and an aromatic boost.

Together, these ingredients create a nourishing, savory dish that’s just as good for you as it is delicious.

Healthy Bison Meatloaf Recipe

Ingredients

2 lbs ground bison (buffalo)
3 garlic cloves, pressed or finely minced
2 eggs, beaten
1⁄4 medium sweet onion, finely minced
1⁄2 teaspoon black pepper
1⁄4 cup seasoned gluten-free breadcrumbs
1⁄4 cup grated Parmesan cheese
1⁄2 teaspoon salt
2 teaspoons Worcestershire sauce
1⁄4 teaspoon ground thyme
1 teaspoon oregano
1 teaspoon basil
1 teaspoon sage

Directions

Preheat oven to 350°F.
In a large bowl, combine all ingredients (using your hands works best).
Add avocado oil or melted ghee to a shallow casserole dish.
Pat the meat mixture evenly into the dish/pan.
Add the meatloaf to the pan then turn it over so it has the cooking oil all over.
Bake for 1 hour 15 minutes to 1 hour 30 minutes, or until cooked through.
Serve warm.
Optional: top with a quick sauce made from 2 parts sugar-free ketchup and 1 part balsamic vinegar (you'll need about 1/4 cup total).

Serving Suggestions

Pair your bison meatloaf with:

No-dairy mashed potatoes (check out this easy recipe!)
Roasted vegetables like Brussels sprouts, broccoli or asparagus
An arugula side salad with olive oil and lemon juice

This combination creates a balanced plate with protein, fiber, healthy fats, and a wide array of micronutrients to leave you feeling nourished and satisfied.

Enjoy!